Lung cancer target drug , lung cancer targeting drugs have several kinds of drug-target drug gene mutations

Lung cancer target drug , lung cancer targeting drugs have several kinds of drug-target drug gene mutations

Listed drugs

Drug	Gene
Carriele Pearl (Erica)	PD-1
Angotini (Fu Kovi)	VEGFR1　 VEGFR2　 VEGFR3　 PDGFR　 FGFR　 c-Kit
Laura Dibini	ALK　 ROS1　 TYK1　 FER　 FPS　 NTRK1　 NTRK2　 NTRK3　 FAK　 FAK2　 ACK
Pasta anti (Pabillezabab) (Can Ruida)	PD-1
Kamten	MET
Colinibi, Serayini (Apply)	ALK
Nawu Baby Anti - Anti - Anti - Appearance	PD-1
Valley, estera, Dwaro monk (Ying Fan)	PD-L1
Ate Zhu Ai, Agal Pearl (Ta Chi)	PD-L1
Ektinib (Kamina)	EGFR
Ohtibini (Terui)	EGFR　 T790M　 HER2　 HER3　 HER4　 ACK1　 BLK
Larone	NTRK1　 NTRK2　 NTRK3
Erlotini (Trokai)	EGFR
Sotorasib	KRAS
Giltinibi (Yi Rui)	EGFR
Eceni	NTRK1　 NTRK2　 NTRK3　 ROS1　 ALK
Afrotini (Gitry)	EGFR　 HER2　 ERBB4
Kazole Dibini (Saurui)	ALK　 MET　 ROS1　 MST1R
Qumeminnib (Miai Ning)	MEK1　 MEK2
Serpteni	RET
Bucadib (Brigtini Guitaine)	ALK　 IGF1R　 ROS1　 FLT3　 EGFR
Nishi beads	EGFR
Dalafa (Tyfei)	BRAF　 CRAF　 SIK1　 NEK11　 LIMK1
Ramucirumab	VEGFR2　 EGFR ALK
Oomatib	EGFR
Pratenini, Prestenib	RET
Enshantini (Beimina)	ALK
Trieli Zhu Mono (Baize An)	PD-1
Enhertu(trastu sheet anti-recombinant freeze-dried powder injection)	HER2
WZ4002	EGFR
Ametib (Amy)	EGFR
Lazine	EGFR
Tepotinib	MET
Naofa	2019-nCoV
Robinkartin
Recombinant human vascular endothelin (En)	VEGFR

Gene of lung cancer , lung cancer gene examination , lung cancer gene detection project , lung cancer gene targeted treatment

 Gene of lung cancer , lung cancer gene examination , lung cancer gene detection project , lung cancer gene targeted treatment

Non-small cell lung cancer susceptible gene

ADH1B

EGFR

PLCE1

PTEN

Non-small cell lung cancer targeted therapy

AKT1	ALK	BRAF	DDR2
EGFR	FGFR1	HER2	KRAS
MEK1	MET	NRAS	PIK3CA
PTEN	RET	ROS1

Non-small cell lung cancer chemotherapy gene

BRCA1	CDA	CYP2C8	CYP2C9*3
DYNC2H1	ERCC1	ERCC2	GSTP1
GSTT1	RRM1	STMN1	Tau
TOP2A	TPMT	TUBB3	TYMS
UGT1A1*28	UGT1A1*6	XPC	XRCC1

Carcinogenic mechanism

Lung cancer treatment method ,lung cancer targeted treatment ,lung cancer has those best treatment (3) - Radiation Therapy

 Radiation Therapy

   First, the treatment principle

    Radiotherapy is the best in small cell carcinoma, squamous cell carcinoma, the worst adenocarcinoma. However, small cell carcinoma is easily metastasis, so many large-area irregular wild uses, the irradiation area should include primary stoves, longitudinal bilateral clavicle, or even liver brain, etc., while supplemented by drug treatment. Squamous cell carcinoma is sensitive to rays, and the lesions are mainly affected, and the transfer is relatively slow, so the use of radical treatment. Adenocarcinoma is poorly sensitive to rays, and it is easy to transfer, so fewer radiotherapy.

    Second, radiation side effects

    There are many complications, even cause loss of partial function; for advanced tumor patients, radiotherapy effect is not good. At the same time, the patient's physical fitness is poor, and the age is not suitable for radiotherapy.

    Third, the adaptation of radiotherapy

    According to the purpose of treatment, score treatment, palliative treatment, preoperative radiotherapy, postoperative radiotherapy and inner radiotherapy.

    

    1. Root treatment

    1) Early cases of surgical taboo or reject surgery, or lesion ranges limit at 150 cm IIIA case;

    2) Heart, lung, liver, kidney function is basically normal, blood white blood cell count is greater than 3 × 10 ^ 9 / L, hemoglobin is greater than 100g / L;

    3) KS ≥ 60 points must be carefully developed carefully, strictly implement, do not change the treatment plan, even if there is a radiation reaction, it should be targeted by root tumors.

    2. Palliative care

    Its purpose is very different. There is a palliative treatment close to the treatment to alleviate the patient's pain, extend life, improve the quality of life; there is only the symptoms of life, or even cause comfort, such as pain, paralysis, coma, anger and bleeding. The number of illuminated times of palliative treatment can be determined from several tens of times, and should be determined according to the specific circumstances and equipment conditions. However, the treatment plan can be modified as appropriate, when the patient does not increase the patient's suffering, when the treatment has a large radiation reaction or the KS score dropped, the treatment plan can be modified as appropriate.

    

    3. Surgical radiotherapy

    It is designed to improve the surgery resection, reduce the risk of tumor spread in intraoperative surgery, and patients with no difficulty in estimating surgery, less divided radiotherapy; such as tumors huge or inverse, it is estimated that surgery is difficult to use. Conventional separation radiotherapy. Radiotherapy is generally less than 50 days from the operation time, and it is not allowed for more than three months.

    4. Surgical radiotherapy

    Used in preoperative estimation, surgery resection of tumor is not thorough. Silver clips should be placed on a local residual leather to accurately position when radiotherapy.

    5. Short-distance radiotherapy in the cavity

    It is suitable for use in the cementation of the large bronchi, which can be placed at a bronchial lesions by a back-mounting technique, and the treatment effect can be improved by iridium (192IR) with ruthenium (192IR).

Lung cancer treatment method ,lung cancer targeted treatment ,lung cancer has those best treatment (2) - Chemotherapy

 Chemotherapy

    Tumor chemotherapy has been rapidly developed in the past 20 years. Chemotherapy for small cell lung cancer, regardless of early or late reports, even have a few revolutions of cure; there is a certain effect on non-small cell lung cancer, but only for palliative, the role is to be further improved. The role of recent chemotherapy in lung cancer is no longer limited to patients with advanced lung cancer that cannot be operated, and is often used as a comprehensive treatment plan for lung cancer in whole body. The chemotherapy will inhibit the bone marrow hematopoietic system, mainly the decline in white blood cells and platelets, combined with traditional Chinese medicine and immunotherapy effect.

    First, small cell lung cancer chemotherapy

    Due to the biological characteristics of small cell lung cancer, there is currently recognized that in addition to a few full evidence indicates that there should be chemotherapy in the chest lymph node metastasis.

   

    1.Adaptation

    1) Small cell lung cancer diagnosed by pathology or cytology;

    2) The KS score is 50-60 minutes or more;

    3) The expected survival time is more than one month;

    4) Age ≤70 years old.

    2. Contraind

    1) Annual old body decrease or malignanosis;

    2) Heart liver and kidney function severe obstacles;

    3) Pleard of bone marrow function in 3 × 10 ^ 9 / L below bloodwheel at 80 × 10 ^ 9 / L (direct count);

    4) There are complications and infection hemorrhage tendency.

    Second, non-small cell lung cancer chemotherapy

    Although non-small cell lung cancer has a lot of effective drugs, it is effective and rarely reaches complete relief.

    

    1. Adaptation

    (1) Patients with pathogenic or cytology confirmed squamous carcinoma or large cell carcinoma but not surgical, and postoperative recurrent metastasis or other reasons for non-surgery III patients;

    (2) Surgical exploration, pathological examination has the following people: 1 has residual stove; 2 lymph node metastasis in the chest; 3 lymphatic or thrombosis cancer; 4 low-differentiated cancer;

    (3) Topical chemotherapy needs to be used with chest or heart-packaged liquid.

    2. Contraindication

    Same small cell carcinoma.

Lung cancer treatment method ,lung cancer targeted treatment ,lung cancer has those best treatment (1) - surgery

surgery

    In the treatment of lung cancer, in addition to surgery or surgical treatment, it is based on surgery, according to different periods and pathological tissue types, the comprehensive treatment of radiotherapy, chemotherapy and immunotherapy. Regarding the survival period after lung cancer surgery, the three-year survival rate is approximately 40% to 60%; the five-year survival rate is about 22% ~ 44%; the surgical mortality rate is less than 3%.

    First, the surgical indication 

    Has the following conditions of the following conditions, generally can be treated:

    1. There is no transfer person, including substantial organs such as liver, brain, adrenal, bone, chest lymph nodes, etc .;

    

    2. Cancer tissue does not have a proliferator adjacent to organs or tissues in the chest, such as aortic, superior venous, esophagus, and cancer van.

    3. No serious heart and lung function is low or the auto-pour pectoris of the near future;

    4. There is no serious and liver and kidney disease and severe diabetes.

    The following conditions should generally be careful for surgery or further examination of treatment:

    1. The year-old bulk is poor;

    2. Small cell lung cancer is preferably chemotherapy or radiotherapy in addition to I, and then determine whether it can be treated;

    3. There are also a few suspicious transferrs seen from the X-ray.

    At present, the academic community is relaxed for the instructions of lung cancer surgery, for some patients who violate the vaschers in the chest and the persistence of isolated from the distance, as long as the physical conditions permit, some scholars also believe that can be surgery, and related explorations. the study.

    Second, the perturbation

    Any surgery taboo, clearly diagnosed as lung cancer or high suspected of lung cancer can select the speculation according to the specific situation, if the lesion has been discovered by the lesion, the original carcinogenesis is still eliminated. In order to reduce the surgery, it does not make a total lung resection so that other treatment is adjusted after surgery.

    Third, the choice of lung cancer

    According to the II and III lung cancer cases in 1985, there is a surgical treatment. The principle of surgical resection is: thoroughly cut lymph nodes that may be transferred in primary stoves and chest, and to keep normal lung tissues as much as possible, all pulmonary resection should be careful.

    1. Local resection: means that the wedge-shaped carcinoma resection and pulmonary resection can be considered for pulmonary local resection of weakness of weakness or low cancer differentiation of the body of the primary carcinogenesis.

    2. Lung leaves: For isolated surrounding lung cancer, there is no obvious lymphadenopathy in a lungs. If the cancer swelling and two-leaf or intermediate bronchi can be vented or lower or lower leaves two leaf pulmonary

    3. Sedied pulp leaves: This type is used in the right lung lung lung cancer, such as cancer swelling in the Ye Yarani, and the viable sleeve pulp is removed;

    4. All lung resection: Where the lesion is widely used by the above method, it can be carefully considered to take care of the whole lung resection when reducing the lesion;

    5. Bronoma and reconstruction: Zum tunoma exceeds the main bronchial tired or tracheal side wall but does not exceed 2 cm: 1 can be made of rhizophore, in addition to reconstruction or cuff-type full lungs; Strive to keep it. The surgery can be determined according to the situation at the time.

    Fourth, the treatment of re-hair or recurrent lung cancer

    1. Treatment of multi-protocker lung cancer: Operation can be removed from cancer, but there is also residual cancer, or region lymph node metastasis, or in vascular suppression, etc., the recurrence transfer chance is very high. Any diagnosis is treated with the second primary stove.

    2. Treatment of recurrent lung cancer: The so-called recurrent lung cancer is a cancerous stove in the scar of the original surgical scar or recurrence with the primary stove, called recurrent lung cancer. The principle of treatment should determine the surgical range according to the patient's cardiopulmonary function and whether it can be removed.